Signal Enhancement in Disperse Solutions for the Analysis of Biomedical Samples by Photothermal Spectroscopy

Authors

  • M.A. Proskurnin Analytical Chemistry Division, Chemistry Department, Lomonosov Moscow State University, Moscow, 119991, Russia
  • D.S. Volkov Analytical Chemistry Division, Chemistry Department, Lomonosov Moscow State University, Moscow, 119991, Russia
  • E.S. Ryndina Analytical Chemistry Division, Chemistry Department, Lomonosov Moscow State University, Moscow, 119991, Russia
  • D.A. Nedosekin Philips Classic Laser Laboratories, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205, USA
  • V.P. Zharov Philips Classic Laser Laboratories, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205, USA

DOI:

https://doi.org/10.12684/alt.1.82

Abstract

Photothermal lens spectrometry not only shows high sensitivity of colored heme protein determination, but also provides a change in the sensitivity compared to the theoretical values due to changes in the heat transfer in dispersed media. This can be used for estimating the size of disperse particles exemplified by hemoglobin cyanide, photothermal examination of the state of existence of hemoglobin in highly saline solutions by changes in photothermal properties upon dissociation of hemoglobin tetramers into dimers and monomers. The example of determination of contrast agents (dyes) in blood as the versification of the platform of photoacoustic/photothermal measurement of circulating blood volume is shown.
ALT 12 Conference, Gwatt, Sept. 2 -6, Switzerland

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Published

2012-11-01

How to Cite

Proskurnin, M., Volkov, D., Ryndina, E., Nedosekin, D., & Zharov, V. (2012). Signal Enhancement in Disperse Solutions for the Analysis of Biomedical Samples by Photothermal Spectroscopy. ALT Proceedings, 1. https://doi.org/10.12684/alt.1.82

Issue

Vol. 1 (2012)

Section

Laser diagnostics and spectroscopy

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