A Unifying Model-Based Hypothesis for the Diverse Waveforms of Infantile Nystagmus Syndrome
Keywords: infantile nystagmus syndrome, mechanism, model, waveforms, simulation
AbstractWe expanded the original behavioral Ocular Motor System (OMS) model for Infantile Nystagmus Syndrome (INS) by incorporating common types of jerk waveforms within a unifying mechanism. Alexander’s law relationships were used to produce desired INS null positions and sharpness. At various gaze angles, these relationships influenced the IN slow-phase amplitudes differently, thereby mimicking the gaze-angle effects of INS patients. Transitions from pseudopendular with foveating saccades to jerk waveforms required replacing braking saccades with foveating fast phases and adding a resettable neural integrator in the pursuit pre-motor circuitry. The robust simulations of accurate OMS behavior in the presence of diverse INS waveforms demonstrate that they can all be generated by a loss of pursuit-system damping, supporting this hypothetical origin.
How to Cite
Wang, Z. I., & Dell’Osso, L. F. (2011). A Unifying Model-Based Hypothesis for the Diverse Waveforms of Infantile Nystagmus Syndrome. Journal of Eye Movement Research, 4(1). https://doi.org/10.16910/jemr.4.1.1
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